KOD DNA polymerase (exo-)

In the Public Domain since

11 May 2020

Description

Abstract

An object of the present invention is to provide a thermostable DNA polymerase with enhanced amplification efficiency and/or improved fidelity in polymerase chain reaction (PCR), and provide a process for production thereof. More specifically, the present invention provides thermostable DNA polymerase wherein in the DX1EX2X3X4H sequence (D: aspartic acid, E: glutamic acid, H: histidine, X1, X2, X3 and X4: any amino acid) consisting of DX1E sequence within the EXO I region and a four amino acid length peptide adjacent to said glutamic acid(E) of thermostable DNA polymerase having 3'-5' exonuclease activity, histidine(H) has been replaced by another amino acid.

Category

Enzymes > DNA Polymerases

Related Inventors

Kuroita, Toshihiro

Source

US Patent No 20,020,076,768

Patent Title: Modified Thermostable Dna Polymerase

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